You have just joined the laboratory of a well-funded AD investigator, who is giving you complete leeway on a project to find a new therapeutic intervention in the disease. Your boss asks you to write a thesis proposal in which you pick a target, justify your choice of target, and design experiments that will explore therapeutic interventions at this particular target. You should take into consideration the numerous failed attempts so far and not repeat them! There is no correct answer (otherwise, we would have a therapy already), but you need to convince your boss of the quality of your reasoning.
