1) Drug Selection: three brands of your drug 2) Decide the dissolution medium and dissolution procedure a. Dissolution buffer preparation b. Dissolution test protocol from BP c. Sample points and length 3) Prepare calibration model for your drug a. Standard solution prepared b. UV absorbance measured: three times for each concentration c. Calibration curve determined 4) Physical testing a. Friability testing b. Uniformity of mass c. Assay of API d. Crushing strength e. Disintegration tests 5. Dissolution tests a. Dissolution tests b. Determining the dissolution profiles c. Comparison of dissolution profiles i. Difference and similarities ii. Model dependence analysis
